24th International Young Scientists Conference Optics and High Technology Material Science - SPO 2023 "STAND WITH UKRAINE"

The Heavy Atom Effect on Spectro-Optical Properties of Pi-electron Containing Molecular Complex Based on Tryptanthrin

17 Nov 2023, 15:20

5m

248 (Taras Shevchenko National University of Kyiv and Shizuoka University)

Poster Poster session

Speaker

Nazarii Tkach (Taras Shevchenko National University of Kyiv)

Description

The Heavy Atom Effect on Spectro-Optical Properties of Pi-electron Containing Molecular Complex Based on Tryptanthrin

Nazarii V. Tkach, Vladislav Yu. Kudrya, Antonina P. Naumenko

Faculty of Physics, Taras Shevchenko National University of Kyiv, 64/13 Volodymyrs’ka str., 01601 Kyiv, Ukraine

Tryptanthrin is a naturally occurring indoloquinazoline alkaloid (Indolo[2,1-b]quinazoline-6,12-dione; C15H8N2O2), the well-known pi-electron-containing compound. It was found in the cells of many plants, microorganisms and in some mammals [1]. Tryptanthrin possesses broad "spectrum" of biological and pharmacological activities due to its feature of easy binding to telomeric G4 DNA and stabilizing it [2,3]. Specifically, platinum complex based on 8-iodo-tryptanthrine possesses the higher anticancer activity than other tryptanthrin derivatives. Our investigations are focused on comparison of spectro-optical properties of the molecular complexes based on tryptanthrin (Try-Pt) and 8-iodo-tryptanthrin (ITry-Pt).
Optical absorption, fluorescence and phosphorescence of Try-Pt and ITry-Pt complexes were investigated. The first excited energy levels positions of these complexes were obtained. The iodine atom effect on spectro-optical properties of tryptanthrin pi-electron system were manifested: the short-wavelength shift of optical absorption spectrum of ITry-Pt in comparison with the corresponding spectrum of Try-Pt, the significant decrease of fluorescence intensity of ITry-Pt in contrast to the corresponding fluorescence intensity of Try-Pt, the short-wavelength shift of fluorescence and phosphorescence spectra of ITry-Pt relative to the corresponding spectra of Try-Pt.

1. B.Pedro, M.Pineiro, A.J.Burke. Synthesis (2022); 54(19): 4235-4245.
2. Q.-P.Qin, B.-Q.Zou, F.-L.Hu, G.-B.Huang, S.-L.Wang, Y.-Q.Gu, M.-X.Tan. Med. Chem. Commun.(2018); 9: 1639-1648.
3. D.Pinheiro, M.Pineiro, J.Pina, P.Brandao, A.M.Galvao, J.S.Seixas de Melo. Dyes and Pigments (2020); 175: 108125.

Presentation Materials

Poster, Nazarii Tkach, Spectro-Luminescent Manifestation of Heavy Atoms Effect on π-Electron System.pdf